Potential Role of Sesamum Indicum L. Supplementation on Body Mass Index Among Mild to Moderate Hyperlipidemic Patients

Sesamum indicum and BMI in hyperlipidemic patients


  • Misbah Arshad University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan
  • Shanai Basharat University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan
  • Shahid Bashir University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan




Sesamum indicum, BMI, Hyperlipidemic, Patients


Hyperlipidemia is the term used to describe abnormally high levels of lipids (fats) in the blood. Cholesterol and triglycerides are the two main types of fat found in blood. Objectives: To investigate the therapeutic potential of Sesamum indicum L. supplementation on BMI among mild to moderate hyperlipidemic patients. Methods: For the four weeks of the trial, 30 mild to moderate hyperlipidemic patients between the ages of 25 and 40 were chosen. The University of Lahore Teaching Hospital in Lahore served as the source of the sample. In a hot air oven, Sesamum indicum L. seeds were roasted for 15 minutes at 200°C. After roasting, seeds were finely powdered using a professional blender. Patients were instructed to follow a 4-week baseline diet regimen and take a daily supplement of 40 mg of Sesamum indicum L. Data on anthropometric measurements, lipid profile biochemical analysis, BMI and nutritional intake were gathered. Results: The mean age of the hyperlipidemic study participants was 32.66 years, with an SD of 4.89 years. The mean weight of study participants before and after therapy were 75.2 ± 1.31 and 73.5 ± 1.10 with a significant difference of 1.7. A striking difference (24%) in the obesity rate between pre and post-treatment was observed. Conclusions: A significant difference in BMI and obesity was observed upon administration of Sesamum indicum seeds in hyperlipidemic patients.


Clebak KT and Dambro AB. Hyperlipidemia: An Evidence-based Review of Current Guidelines. Cureus. 2020 Mar; 12(3):e7326. doi: 10.7759/cureus.7326

Sarfraz M, Sajid S, Ashraf MA. Prevalence and pattern of dyslipidemia in hyperglycemic patients and its associated factors among Pakistani population. Saudi Journal of Biological Sciences. 2016 Nov; 23(6):761-766. doi: 10.1016/j.sjbs.2016.03.001

Qudoos A, Nia K, Hakro S, Murad S. Single blind placebo-controlled study on comparision of effects of zingiber officinale before and after treatment in hyperlipidemia. Journal of Drug Delivery and Therapeutics. 2016 May; 6(3):90-2. doi: 10.22270/jddt.v6i3.1239

Burkhardt R. Hyperlipidemia and cardiovascular disease: new insights on lipoprotein(a). Current Opinion Lipidology. 2019 Jun; 30(3):260-261. doi: 10.1097/MOL.0000000000000594

Shasmitha R. Health benefits of Sesamum indicum: A short review. Asian Journal of Pharmaceutical and Clinical Research. 2015; 8(6):1-3.

Elleuch M, Besbes S, Roiseux O, Blecker C, Attia H. Quality characteristics of sesame seeds and by-products. Food chemistry. 2007 Jan; 103(2):641-50. doi: 10.1016/j.foodchem.2006.09.008

Vittori Gouveia LD, Cardoso CA, de Oliveira GM, Rosa G, Moreira AS. Effects of the intake of sesame seeds (Sesamum indicum L.) and derivatives on oxidative stress: A systematic review. Journal of medicinal food. 2016 Apr; 19(4):337-45.

Qadir A, Singh SP, Akhtar J, Ali A, Arif M. Phytochemical and GC-MS analysis of Saudi Arabian Ajwa variety of date seed oil and extracts obtained by the slow pyrolysis method. Oriental Pharmacy and Experimental Medicine. 2017 Mar; 17(1):81-7. doi: 10.1007/s13596-017-0257-y

Arif M, Fareed S, Hussain MS. Estimation of antioxidant activity of microwave assisted extraction of total phenolics and flavonoids contents of the fruit Spondias mangifera Willd. Asian Journal of Traditional Medicines. 2011 Aug; 6(4):145-53.

Sachan NK, Arif M, Zaman K, Kumar Y. Anti-inflammatory, analgesic and antioxidant potential of the stem bark of Spondias mangifera Willd. Archives of Biological Sciences. 2011; 63(2):413-9. doi: 10.2298/ABS1102413S

Pathak N, Bhaduri A, Rai AK. Sesame: Bioactive compounds and health benefits. InBioactive molecules in food 2019 (pp. 181-200). Springer, Cham. doi: 10.1007/978-3-319-78030-6_59

Devarajan S, Singh R, Chatterjee B, Zhang B, Ali A. A blend of sesame oil and rice bran oil lowers blood pressure and improves the lipid profile in mild-to-moderate hypertensive patients. Journal of Clinical Lipidology. 2016 Apr; 10(2):339-49. doi: 10.1016/j.jacl.2015.12.011

Chennuru A and Saleem MT. Antioxidant, lipid lowering, and membrane stabilization effect of sesamol against doxorubicin-induced cardiomyopathy in experimental rats. Biomed Research International. 2013; 2013:934239. doi: 10.1155/2013/934239

Luijten J, van Greevenbroek MMJ, Schaper NC, Meex SJR, van der Steen C, Meijer LJ, et al. Incidence of cardiovascular disease in familial combined hyperlipidemia: A 15-year follow-up study. Atherosclerosis. 2019 Jan; 280:1-6. doi: 10.1016/j.atherosclerosis.2018.11.013

Ballantyne CM, Grundy SM, Oberman A, Kreisberg RA, Havel RJ, Frost PH, et al. Hyperlipidemia: diagnostic and therapeutic perspectives. The Journal of Clinical Endocrinology and Metabolism. 2000 Jun; 85(6):2089-112. doi: 10.1210/jcem.85.6.6642-1

Munshi RP, Joshi SG, Rane BN. Development of an experimental diet model in rats to study hyperlipidemia and insulin resistance, markers for coronary heart disease. Indian Journal of Pharmacology. 2014 Jun; 46(3):270-6. doi: 10.4103/0253-7613.132156

Shishehbor F, Hojati N, Jahanshahi AR, Haghighizadeh M. Effects of sesame seed consumption on anthropometric indices, lipid profile and atherogenic index of plasma in women with metabolic syndrome.

Helli B, Mowla K, Mohammadshahi M, Jalali MT. Effect of Sesamin Supplementation on Cardiovascular Risk Factors in Women with Rheumatoid Arthritis. Journal of the American College of Nutrition. 2016 Jun; 35(4):300-7. doi: 10.1080/07315724.2015.1005198

Rao W, Su Y, Yang G, Ma Y, Liu R, Zhang S, et al. Cross-Sectional Associations between Body Mass Index and Hyperlipidemia among Adults in Northeastern China. International Journal of Environmental Research and Public Health. 2016 May; 13(5):516. doi: 10.3390/ijerph13050516

Kawada T. Body mass index is a good predictor of hypertension and hyperlipidemia in a rural Japanese population. International Journal of Obesity and Related Metabolic Disorders. 2002 May; 26(5):725-9. doi: 10.1038/sj.ijo.0801984



DOI: 10.54393/mjz.v1i2.42
Published: 2020-12-31

How to Cite

Arshad, M. ., Basharat, S. ., & Bashir, S. . (2020). Potential Role of Sesamum Indicum L. Supplementation on Body Mass Index Among Mild to Moderate Hyperlipidemic Patients: Sesamum indicum and BMI in hyperlipidemic patients. MARKHOR (The Journal of Zoology), 1(2), 32–35. https://doi.org/10.54393/mjz.v1i2.42



Original Article

Most read articles by the same author(s)