Chronic Liver Disease and it’s Complications
Liver diseases progresses to more severe forms and thus are a major health problem. Cirrhosis and primitive liver cancer are significantly important in the west and are among the first 10 causes of death in adults. In all chronic liver diseases the final common pathway is liver cirrhosis, characterized by an accumulation of extracellular matrix rich in fibrillar collagens. Cirrhotic patients are at risk of developing many potential complications.One of the major complications of CLDs is Portal hypertension (PH),leads to the progression of portal vein-systemic collateral circulation that includes portal hypertensive gastropathy (PHG) and esophageal and gastric varices. Disabling and distressing manifestation of liver cirrhosis is tense ascites. In the presence of ascites alteration occurs in ventricular function. Cirrhosis may cause renal dysfunction, a common and potentially life threatening complication in hospitalized patients. Both acute kidney injury (AKI) and chronic kidney injury (CKD) are most common, often occurring simultaneously.
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